Breast Cancer Metastasis to the Bone Microenvironment
A majority of breast cancer patients develop metastases in their bone, and the bone microenvironment plays a large role in recruiting tumor cells from the breast.
Posted by John Lee on Thursday, May 20th, 2021 in May 2021, adipocytes, bone metastasis, breast cancer, stiffness
Liposome-based Strategies to Mitigate Ischemic Stroke-induced Neurodegeneration
Liposome-based drug delivery to the brain is a well-established and an effective approach for delivering neuroprotectants across the BBB in ischemic stroke.
Posted by John Lee on Thursday, May 20th, 2021 in May 2021, Blood Brain Barrier, Drug Delivery Systems, Liposomes, Stroke
Removing Dark Region Artifacts using Deep Neural Networks with a Hyperparameter Search
This study used deep neural networks to remove dark region artifacts in order to create clearer ultrasound images.
Posted by John Lee on Wednesday, May 19th, 2021 in May 2021, Deep Neural Network, Machine learning, Ultrasound
Radiation Emissions of Primordial Black Holes as Dark Matter in a Dwarf Galaxy
Dark matter in a simulated dwarf galaxy was replaced with primordial black holes and the resulting radiation is analyzed.
Posted by John Lee on Thursday, December 24th, 2020 in May 2018, Cosmological Simulations, dark matter, Primordial Black Holes
Analyzing the role of endothelial cell derived Jedi-1 in postnatal neurogenesis
Neural stem cells experience a decrease in quiescence in the absence of Jedi-1 positive endothelial cells.
Posted by John Lee on Wednesday, December 23rd, 2020 in May 2020, Endothelial cells, Jedi-1, neural stem cells, Neurogenesis
Feasibility assessment of heat transfer as an independent variable to compare cold exposure studies of brown adipose tissue
A flow-temperature sensing device was incorporated into a water-blanket system to calculate heat transfer for use as an independent varia-ble in cooling studies
Posted by John Lee on Wednesday, December 23rd, 2020 in May 2020, brown adipose tissue, cold exposure, thermoregulatory physiology
Validating a Dual-Threshold Peak Detection for Calcium Signals Around Laser-Induced Epithelial Wounds
A comparison between an automated method of collection calcium peaks to a manual version to determine the accuracy of the automated system and gain insight into the role of calcium during the wound healing process.
Posted by John Lee on Wednesday, December 23rd, 2020 in May 2020, Calcium Signals, Peaks Detection
Analyzing the Spatial Organization of Tuberous Sclerosis Complex Tumor Cells Using Immunostaining and Computational Approaches
Immunostaining and Computational approaches through the HistoCAT software determined a non-random organization of cells in Subependymal Giant-Cell Astrocytomas (SEGAs), a type of Tuberous Sclerosis Complex tumor.
Posted by John Lee on Wednesday, December 23rd, 2020 in May 2020, HistoCAT, Pax6., Tuberous Sclerosis Complex
Provenance of Zircon in McMurdo Sound Antarctica
This study analyzes the ages of zircon minerals found in the ANDRILL core in order to track past ice flow.
Posted by John Lee on Wednesday, December 23rd, 2020 in May 2020, ANDRILL, Isotope, Provenance, Zircon
Interactive Anatomy and Physiology Augmented Reality Application
An interactive augmented reality prototype application was created as an interactive educational tool for the classroom.
Posted by John Lee on Tuesday, December 22nd, 2020 in May 2019, Augmented reality, education, musculoskeletal, prototype
Utilizing Camera Traps to Analyze Relative Abundance of Basking Turtles in Wetland Ecosystems
Solar irradiance positively influences the time of day at which red-eared sliders bask in wetland ecosystems.
Posted by John Lee on Tuesday, December 22nd, 2020 in May 2019, Biological clocks, habitat degradation, invasive species, physiological responses, thermoregulation
Analyzing homozygous loss of TSC2 mutants in human iPSC-derived neural spheres.
Early neural progenitors with tuberous sclerosis are larger and more disorganized than those without.
Posted by John Lee on Tuesday, December 22nd, 2020 in May 2019, Neurology, stem cell, tuberous sclerosis
Using MicroCT to Improve Precision of Uranium-Thorium Dating in Speleothem Records
Avoiding impurities by using microCT to look below stalagmite surfaces leads to more precise age models and better climate records.
Posted by John Lee on Tuesday, December 22nd, 2020 in May 2019, MicroCT, Speleothems, Uranium-Thorium Dating
Building a Konstanz Information Miner (KNIME) pipeline to assess the utility of immunofluorescence computational analysis of ALCAM in bladder cancer
A KNIME pipeline for performing single-cell, multiplex immunofluorescence
Posted by John Lee on Tuesday, December 22nd, 2020 in May 2018, ALCAM, bladder cancer, KNIME, single-cell analysis
Quantifying Young’s Modulus of Gelatin Substrates for in vitro BBB Models
An examination of the effect of gelatin concentration on Young’s Modulus preformed for future in vitro Blood Brain Barrier studies.
Posted by John Lee on Tuesday, December 22nd, 2020 in May 2018, Blood Brain Barrier, in vitro, Young’s Modulus
Concrete Printing System Construction and Characterization of 3-D Printed Cement-based Materials
Cement-based materials were designed and printed on a novel extrusion system, then characterized.
Posted by John Lee on Tuesday, December 22nd, 2020 in May 2018, 3-D Printing, Additive Manufacturing, Cement, Microstructure, Mix Design
The role of fructose in the expression of extracellular matrix markers and cytokines released by M1 and M2 macrophages that regulate the progression of nonalcoholic fatty liver disease
The role of the sugar fructose on the induction of extracellular matrix proteins and inflammation in polarized macrophages.
Posted by John Lee on Tuesday, December 22nd, 2020 in May 2018, fructose, Macrophages, Nonalcoholic fatty liver disease
Recovery of Putative Temperature-Sensitive Mutations in Coro-navirus Nonstructural Protein 5 Reveals Conserved Determi-nants of nsp5 Structure
This study identifies temperature-sensitive mutations as conserved determinants in coronavirus nsp5 proteins of strains HKU1 and OC43.
Posted by Greta Clinton-Selin on Wednesday, June 28th, 2017 in May 2013, Coronavirus, Nonstructural Protein 5, Temperature-Sensitive Mutations
Using Detrital Zircon Age Distributions to Corroborate Evidence of Early Holocene Megafloods
Zircon grain age distributions provide information on the origins of early holocene megaflood related sediment.
Posted by Greta Clinton-Selin on Thursday, June 8th, 2017 in May 2017, arsenic, Groundwater, Megaflood, Zircon
Development of a Portable and Inexpensive Ultrasound Imaging Device for Use in the Developing World
A portable and inexpensive ultrasound device that could be used in the developing world was developed and tested.
Posted by Greta Clinton-Selin on Thursday, June 8th, 2017 in May 2017, BeagleBone, Phantom, Portable, Ultrasound
Bulk Mechanical Characterization of Nanoparticle Concrete-Equivalent Mortars
Ultimate concrete strength was studied as a factor of both mass and surface area of nanoparticles added to the material.
Posted by Greta Clinton-Selin on Wednesday, June 7th, 2017 in May 2017, compressive strength, concrete, mass, Nanoparticles, nuclear waste storage, surface area
Creating an Agent-Based Model to Explore the Spread of Zika Virus
Predicted Zika outbreak severity directly correlates with human population density.
Posted by Greta Clinton-Selin on Tuesday, May 30th, 2017 in May 2017, Agent-based modeling, Zika Virus
POPDC3 Regulates Epithelial-Mesenchymal-Transition in Colorectal Cancer Cells
The POPDC3 protein was identified as a potential regulator of the epithelial-mesenchymal-transition process in colorectal cancer.
Posted by Greta Clinton-Selin on Wednesday, May 24th, 2017 in May 2017, colorectal cancer, epithelial-mesenchymal transition, Popdc3
Characterization of the Downstream Effects of Apical Mistrafficking of Epiregulin and Potential for Transformation in Polarized Epithelial Cells
Loss of epithelial polarity and mistrafficking of Epiregulin may be a driving force for cancer in polarized epithelial cells.
Posted by Greta Clinton-Selin on Wednesday, June 29th, 2016 in May 2016, Apical, Basolateral, cancer, Epiregulin (EREG), Trafficking
Classification of Infant Cries Using Acoustic Features
Identifying an acoustic feature combination that can accurately differentiate between infant cries.
Posted by Greta Clinton-Selin on Wednesday, June 29th, 2016 in May 2016, classification, cries, features, Matlab, NICU, pain
Determining the Turning Wing Kinematics of a Ruby-Throated Hummingbird
The turning wing kinematics of a ruby-throated hummingbird are determined by use of a blade element model.
Posted by Greta Clinton-Selin on Wednesday, June 8th, 2016 in May 2016, blade element model, computational fluid dynamics, Micro Aerial Vehicles
Improving Patterned Nanoporous Gold as an Effective Surface Enhanced Raman Scattering Template
An imprinted nanoporous gold substrate was optimized to create a low power Raman biological and chemical sensor.
Posted by Greta Clinton-Selin on Tuesday, June 7th, 2016 in May 2016,
Regulation of Pro-Inflammatory Phenotypes by Carcinogenic and Non-Carcinogenic Helicobacter pylori strains
In order to quantify H. pylori virulence, the concentration of IL-8 secreted by AGS gastric epithelial cells co-culture with H. pylori strains, isolated from patients with gastritis or gastric adenocarcinoma was measured and compared.
Posted by Greta Clinton-Selin on Thursday, June 2nd, 2016 in May 2016, gastric cancer, gastritis, Helicobacter pylori, Interleukin-8
Effect of NRIF on p75 Expression
NRIF may be a transcriptional repressor of p75 expression.
Posted by Greta Clinton-Selin on Tuesday, October 20th, 2015 in May 2014, brain, central nervous system, NRIF, p75
IL-6 Secreted from Pancreatic Stellate Cells Activates STAT3 and Promotes Cell Growth and Invasive Ability of Pancreatic Cancer
IL-6 Secreted from Pancreatic Stellate Cells Activates STAT3 and Promotes Cell Growth and Invasive Ability of Pancreatic Cancer
Posted by Printess Berry on Thursday, October 15th, 2015 in May 2014, IL-6 STAT3, Pancreatic ductal adenocarcinoma (PDAC), pancreatic stellate cells (PSCs)