Four variations of the PTHrP promoter were tested to determine which yielded the highest PTHrP expression in order to discern which region is most important for Gli2 activation of PTHrP in Tumor-Induced Bone Disease.
Hedgehog pathway inhibitors were established as potential remediation treatments for tumor-induced bone disease. Additionally, hypotheses concerning inhibition methods were established for future investigation.
Characterization of Novel Drugs that Target the Hedgehog Signaling Pathway in Tumor Induced Bone Disease
This research presents information about optimized transfection conditions for MDA-MB- 231 cells, as well as cell viability data on known antagonists.