‘Gli2’
Gli2 Regulation of Parathyroid Hormone-Related Protein Expression in Metastatic Breast Cancers
Four variations of the PTHrP promoter were tested to determine which yielded the highest PTHrP expression in order to discern which region is most important for Gli2 activation of PTHrP in Tumor-Induced Bone Disease.
Posted by John Lee on Tuesday, December 22nd, 2020 in May 2018, Gli2, Metastatic Breast Cancer, Promoter, PTHrP, Tumor-Induced Bone Disease
Assessment of Hedgehog/GLI2 signaling inhibitors within metastatic breast cancers
Hedgehog pathway inhibitors were established as potential remediation treatments for tumor-induced bone disease. Additionally, hypotheses concerning inhibition methods were established for future investigation.
Posted by Greta Clinton-Selin on Friday, June 3rd, 2016 in May 2016, Gli2, Hedgehog Pathway Inhibitor, Metastatic Breast Cancer, PTHrP
Characterization of Novel Drugs that Target the Hedgehog Signaling Pathway in Tumor Induced Bone Disease
This research presents information about optimized transfection conditions for MDA-MB- 231 cells, as well as cell viability data on known antagonists.
Posted by Greta Clinton-Selin on Wednesday, April 29th, 2015 in May 2015, Bone metastases, Gli2, Hedgehog Signaling Pathway